![]() 2 An elevated CK level is the most sensitive laboratory test for evaluating an injury to muscle that has the potential to cause rhabdomyolysis (assuming no concurrent cardiac or brain injury). However, this rigid depiction of symptoms can be misleading as the triad is only observed in 50% of patients do not complain of muscle pain or weakness, with the initial presenting symptom being discolored urine. 10, 11Ĭlinically, rhabdomyolysis is exhibited by a triad of symptoms: myalgia, weakness, and myoglobinuria, manifested as the classically described tea-colored urine. 9 Bywaters and Beall are often credited with the first account of the pathophysiologic mechanisms of the syndrome and the accurate depiction of the link between rhabdomyolysis and ARF. 7, 8 In modern times, one of the first medical descriptions of rhabdomyolysis is in German medical literature from the early 1900s, where it is termed Meyer-Betz disease. 5, 6 Myolysis seemingly occurs because of the poisonous hemlock that quail consume during the spring migration. 4 The plague is widely assumed to be a reference to the signs and symptoms of myolysis, a long-observed outcome in the Mediterranean after the intake of quail. The earliest known description of this condition appears in the Old Testament's Book of Numbers that records a plague suffered by the Jews during their exodus from Egypt after consuming large amounts of quail. 2 Massive necrosis, manifested as limb weakness, myalgia, swelling, and commonly gross pigmenturia without hematuria, is the common denominator of both traumatic and nontraumatic rhabdomyolysis. 1 Although rhabdomyolysis is most often caused by direct traumatic injury, the condition can also be the result of drugs, toxins, infections, muscle ischemia, electrolyte and metabolic disorders, genetic disorders, exertion or prolonged bed rest, and temperature-induced states such as neuroleptic malignant syndrome (NMS) and malignant hyperthermia (MH). Rhabdomyolysis ranges from an asymptomatic illness with elevation in the CK level to a life-threatening condition associated with extreme elevations in CK, electrolyte imbalances, acute renal failure (ARF), and disseminated intravascular coagulation. This disruption of skeletal muscle integrity leads to the direct release of intracellular muscle components, including myoglobin, creatine kinase (CK), aldolase, and lactate dehydrogenase, as well as electrolytes, into the bloodstream and extracellular space. Rhabdomyolysis is a complex medical condition involving the rapid dissolution of damaged or injured skeletal muscle.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |